Novel methods, mechanistic insight, and personalized treatments to improve mental health

Personalizing Brain Stimulation
Our goal is to understand the fundamental principles of human brain plasticity and build trans-diagnostic real-time monitoring platforms for personalized neurotherapeutics.
We use an array of neuroscience methods to better understand the basic principles of how to create change in brain circuits. We use this knowledge to develop more effective treatment strategies for depression and other psychiatric disorders.
click image for more details

MISSION
Mental health is central to our well being, our relationships, and to society. Unfortunately, mental healthcare is often applied in a one-size-fits-all manner, cycling through multiple treatments without reference to one’s biology as a guide, leading to reduced efficacy.
To change this, through scientific and ethical rigor we seek to better understand the fundamental principles and develop new tools to quantify 1) how brain circuits interact, 2) how treatments change these circuits, and 3) how these changes map onto clinical symptoms. A deep knowledge of the relationship between brain circuits and symptoms will reduce the stigma around mental health and translate to targeted, personalized, and more effective treatments.
The goal of our laboratory is to develop an environment conducive to team-based learning in order to train the next generation of clinically-informed circuit neuroscientists. We will be recognized for questioning the status quo with rigorous scientific experiments and will make important scientific contributions in understanding how brain stimulation alters neural circuits and behavior.
Corey Keller MD, PhD
Principal Investigator

Appointments
-
Assistant Professor, Psychiatry & Behavioral Sciences, Stanford University
-
Member, Wu Tsai Neurosciences Institute
-
Member, Bio-X
Education
-
Residency, Stanford University
-
MD and PhD in Neuroscience, Albert Einstein College of Medicine
-
BS in Electrical and Biomedical Engineering, Tufts University
Funding
-
NIMH R01 (2)
-
BWF Career Award for Medical Scientists
-
NIH Director's Early Independence Award DP5
-
NIMH K23 award (completed)
-
NIINDS F31 (completed)
External Links
PUBLICATIONS




Featured publications:
Intracortical dynamics underlying repetitive stimulation predicts changes in network connectivity
Journal of Neuroscience 2019
Neuropsychopharmacology 2019
Induction and quantification of excitability changes in human cortical networks
Journal of Neuroscience 2018
ARTIST: A Fully Automated Artifact Rejection Algorithm for Single-Pulse TMS-EEG Data
Neuroimage 2018
Tuning face perception with electrical stimulation of the fusiform gyrus
Cerebral Cortex 2017
The Limited Utility of Multiunit Data in Differentiating Neuronal Population Activity
PLoS One 2016
Mapping complex brain networks with cortico-cortical evoked potentials
Philos Trans R Soc Lond B Biol Sci.2014
Journal of Neuroscience 2015
Cortico-cortical evoked potentials reveal projectors and integrators within human brain networks
Journal of Neuroscience 2013
Intrinsic functional architecture predicts electrically-evoked responses in the human brain
Proceedings of the National Academy of Sciences 2011

JOIN US
Please reach out if you would like to explore opportunities to join us! We are currently hiring:
More information can be found here
Stanford University
401 Quarry Road, Stanford, CA
Palo Alto VA
3801 Miranda Road, Palo Alto, CA